The Kawate Lab


Research papers

Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, and Kawate T. (2020) The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition eLife. DOI: 10.7554/eLife.54670

Michalski K, Henze E, Nguyen P, Lynch P, and Kawate T. (2018) The weak voltage dependence of pannexin 1 channels can be tuned by N-terminal modifications J Gen Physiol. DOI: 10.1085/jgp.201711804

Karasawa A, Michalski K, Mikhelzon P, and Kawate T. (2017) The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition eLife, 6:e31186

Karasawa A and Kawate T. (2017) Expression and Purification of a Mammalian P2X7 Receptor from Sf9 insect Cells Bio Protoc, Sep 05;7(17)

Karasawa A and Kawate T. (2016) Structural basis for subtype-specific inhibition of the P2X7 receptor eLife, 5:e22153

Michalski K and Kawate T. (2016) Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop J Gen Physiol. 147(2):165-74

Richards MJ, Hsia CY, Singh RR, Haider SH, Kumpf JM, Kawate T, and Daniel S. (2016) Membrane protein mobility and orientation preserved in supported bilayers created directly from cell plasma membrane blebs Langmuir. 32(12):2963-74.

Review papers

Kawate T. (2017) P2X Receptor Activation Adv Exp Med Biol.

Selected papers prior to Cornell

Kawate T, Robertson JL, Li M, Silberberg SD, and Swartz KJ. (2011) Ion access pathway to the transmembrane pore in P2X receptor channels J Gen Physiol. 137(6):579-90.

Li M, Kawate T, Silberberg SD, and Swartz KJ. (2010) Pore-opening mechanism in trimeric P2X receptor channels Nature Communications. 1:44

Kawate T, Carlisle MJ, Birdsong WT, and Gouaux E. (2009) Crystal structure of the ATP-gated P2X4 ion channel in the closed state Nature. 460(7255):592-8

Gonzales EB, Kawate T, and Gouaux E. (2009) Pore architecture and ion sites in acid sensing ion channels and P2X receptors Nature. 460(7255):599-604

Kawate T and Gouaux E. (2006) Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins Structure. 14(4):673-681

Yamashita A, Singh SK, Kawate T, Jin Y, and Gouaux E. (2005) Crystal structure of a bacterial homologue of Na+/Cl- dependent neurotransmitter transporters Nature. 437(7056):215-23

Takeda T, Kawate T, and Chang F. (2004) Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast Nature Cell Biology. 6(11):1142-4

Kawate T and Gouaux E. (2003) Arresting and releasing Staphylococcal α-hemolysin at intermediate stages of pore formation by engineered disulfide bonds Protein Science. 12(5):997-1006